OPA1’s shortcut to mitochondrial fission
نویسندگان
چکیده
منابع مشابه
Mitochondrial fission and fusion.
Mitochondria are highly dynamic cellular organelles, with the ability to change size, shape and position over the course of a few seconds. Many of these changes are related to the ability of mitochondria to undergo the highly co-ordinated processes of fission (division of a single organelle into two or more independent structures) or fusion (the opposing reaction). These actions occur simultane...
متن کاملMechanical force induces mitochondrial fission
Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive networks constantly remodeled by fission and fusion. Here, we show that mitochondrial fission is triggered by mechanical forces. Mechano-stimu...
متن کاملPreventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA
Mitochondria form a highly dynamic tubular network, the morphology of which is regulated by frequent fission and fusion events. However, the role of mitochondrial fission in homeostasis of the organelle is still unknown. Here we report that preventing mitochondrial fission, by down-regulating expression of Drp1 in mammalian cells leads to a loss of mitochondrial DNA and a decrease of mitochondr...
متن کاملMitochondrial Fission and Remodeling Contributes to Muscle Atrophy
Thank you for submitting your manuscript for consideration by The EMBO Journal. Your manuscript has been reviewed by three referees and I enclose their reports below. As you will see from their comments the referees overall express interest in the study and require additional experiments before the study is suitable for the EMBO Journal. The referees ask for a number of experiments and referee ...
متن کاملModulating Mitochondrial Fission to Lower Diabetic Oxidative Stress
Mitochondria are at the crossroads of energy metabolism, and they play a major role in the regulation of cell life and death. Mitochondrial oxidation of fat and glucose substrates generates a transmembrane electrochemical gradient, and this is used to synthesize adenosine triphosphate (ATP), the chemical fuel for cell and tissue functions. In the process, electron transfer through the mitochond...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2014
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2046iti2